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4) Researchers sought to understand the genetic basis | Chegg.com
RNA and Disease: Cell
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Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide | PNAS
RNA toxicity and foci formation in microsatellite expansion diseases. - Abstract - Europe PMC
Biomolecules | Free Full-Text | Oxidative Stress in DNA Repeat Expansion Disorders: A Focus on NRF2 Signaling Involvement
TNFR1-d2 carrying the p.(Thr79Met) pathogenic variant is a potential novel actor of TNFα/TNFR1 signalling regulation in the pathophysiology of TRAPS | Scientific Reports
Application of CRISPR-Cas9-Mediated Genome Editing for the Treatment of Myotonic Dystrophy Type 1: Molecular Therapy
A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells | eLife
The good, the bad, and the ugly: Evolutionary and pathological aspects of gene dosage alterations | PLOS Genetics
Dynamics of the Proline-Rich C-Terminus of Huntingtin Exon-1 Fibrils. - Abstract - Europe PMC
Insects | Free Full-Text | CRISPR/Cas9-Mediated Mutagenesis of Abdominal-A and Ultrabithorax in the Asian Corn Borer, Ostrinia furnacalis
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In heart failure reactivation of RNA-binding proteins is associated with the expression of 1,523 fetal-specific isoforms | PLOS Computational Biology
Identification and characterization of the fusion transcript, composed of the apterous homolog and a putative protein phosphatase gene, generated by 1.5-Mb interstitial deletion in the vestigial (Vg) mutant of Bombyx mori -
RNA toxicity in non‐coding repeat expansion disorders | The EMBO Journal
Small Molecule Screening Discovers Compounds that Reduce FMRpolyG Protein Aggregates and Splicing Defect Toxicity in Fragile X-Associated Tremor/Ataxia Syndrome | SpringerLink
IJMS | Free Full-Text | A Novel Huntington’s Disease Assessment Platform to Support Future Drug Discovery and Development
Insects | Free Full-Text | CRISPR/Cas9-Mediated Mutagenesis of Abdominal-A and Ultrabithorax in the Asian Corn Borer, Ostrinia furnacalis